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Understanding Organ and Tissue Donation - The GIVE Trigger

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For those Australians facing chronic illness, disability and death, organ and tissue donation is a well-established means of effective treatment. Yet despite recent advances and reforms that have resulted in strong growth in donation rates, the demand for donors continues to exceed availability (Organ and Tissue Authority 2014, p. 5).

Australia’s Potential Organ Donor Population

(Organ and Tissue Authority 2015)

Transplantable organs can be the heartlungskidneysliverpancreas and intestine, and possible donation tissues include heart valves and other heart tissuemusculoskeletal tissueskin and parts of the eye (Organ and Tissue Authority 2016). Nurses have the power and responsibility to be an advocate for their patients and their loved ones, as well as future donor recipients, by knowing when to refer any potential donors on to relevant teams.

The way in which a person dies influences which organs and tissues are available for donation and the way the donation process occurs (Organ and Tissue Authority 2016). Before donation can take place, death must be determined in one of two ways: brain death or cardiac death.

Tissue Donation

All deceased persons can be referred as potential tissue donors. Subject to medical suitability assessment and relevant donor checks, the process may or may not go ahead. Most tissue retrieval can take place up to twenty four hours after death, and age limits range from sixty years for heart tissue, to ninety nine years for eye tissue (Curtis & Ramsden 2012).

Donation After Brain Death

When there is severe brain injury, an increase in the intracranial pressure causes inadequate perfusion pressure of the brain. This creates a cycle of marked cerebral ischaemia and oedema, which in turn further elevates intracranial pressure (Australia and New Zealand Intensive Care Society [ANZICS] 2010). Once intracranial pressure exceeds systemic blood pressure, and therefore ceasing intracranial blood flow, death of the whole brain and brain stem occurs (ANZICS 2010). Severe head injury, stroke or haemorrhage, tumours or infection are all causes of brain death.

The Australian and New Zealand Intensive Care Society (2010), states that determination of brain death must be conducted by two senior doctors, performing the same set of tests to see if the patient has any of the following:

  • Response to painful stimuli
  • Brain stem reflexes (pupillary response to light, blinking response when the cornea is touched, eye movement when cold water is instilled in the ear canal)
  • Cough or gag reflex when the back of the throat is stimulated
  • Ability to spontaneously breathe when disconnected from the ventilator


In certain circumstances where clinical testing of brain death cannot occur, such as facial trauma or the presence of sedative drugs, then a CT angiogram or perfusion scan are conducted to check for blood flow to the brain (Curtis & Ramsden 2012).

Once brain death has been determined, and if organ donation is to go ahead, the patient is then transferred to the operating theatre where the organ and tissue retrieval surgery will take place. The ventilator is removed during the operation and the patients’ heart will stop beating (Organ and Tissue Authority 2016).

Donation After Cardiac Death

The signs of cardiac death or cessation of circulation and absence of life are well known and commonly seen in medicine. It can occur suddenly or after a long illness, and the patient may not necessarily be brain dead, but has sustained such severe injuries that they cannot breathe on their own (ANZICS 2010). Once it is clear that ongoing treatment while the patient is on the ventilator will be unsuccessful, and if organ donation is to be attempted, the patient is moved to the operating theatre where the ventilator is turned off. Organ donation can only go ahead if death is determined within ninety minutes of turning off the ventilator, as the organ will begin to deteriorate after this time due to lack of oxygenation (ANZICS 2010).

Cardiac death is determined when all of the following have occurred:

  • Immobility
  • Apnoea
  • Skin perfusion has ceased
  • Absence of circulation for a minimum of two minutes (measured by feeling for a pulse or monitoring intra-arterial pressure)

(ANZICS 2010)

GIVE Trigger

The early identification and referral of potential organ and tissue donors can be initiated in most cases in the emergency department, through the use of the GIVE clinical trigger. It denotes part of the systematic approach to organ and tissue donation and asks staff to contact their applicable donation team, whether it be a hospital-based liaison or state donation agency, when no further treatment options are appropriate or available, and the patient meets the trigger criteria.

  • G – a GCS of five or less
  • I – intubated
  • V – ventilated
  • E – end of life care

(Curtis & Ramsden 2012)

The end of life discussion with family members or guardians may or may not have been conducted at this stage, however this does not mean referral cannot be made, and in some cases the donation team may be the most appropriate people to approach the possibility of organ donation with those involved in the decision.

With Australia’s aging population and the incidence of chronic disease on the rise, further improvements in donation rates and transplantation outcomes need to be made in order to meet the current and future needs of those requiring organ and tissue donation. Nurses are often the ones directly involved in patient care, and the main contact for patients’ families and loved ones. As already mentioned, this enables us to be able to foresee and refer any potential donors in a sensitive manner, allowing for an informed, dignified and respectful decision making process.

[show_more more=”Show References” less=”Hide References” align=”center” color=”#808080″]

  • Australian and New Zealand Intensive Care Society 2010, The ANZICS Statement on Death and Organ Donation, 3rd edn, Melbourne, VIC, Australia.
  • Australian Government Organ and Tissue Authority 2014, Organ and Tissue Donation for Transplantation in Australia 2014-2018 Strategic Plan, OTA, Canberra, ACT, Australia, viewed 11 July 2016, http://www.donatelife.gov.au…Plan.pdf
  • Australian Government Organ and Tissue Authority 2015, Organ and Tissue Donation for Transplantation in Australia 2015-2019 Strategic Plan, OTA, Canberra, ACT, Australia, viewed 17 July 2016, http://www.donatelife.gov.au/s…Plan.pdf
  • Australian Government Organ and Tissue Authority 2016, Understanding the Donation Process, OTA, Canberra, ACT, Australia, viewed 13 July 2016, http://www.donatelife.gov.au/understanding-donation-process
  • Curtis, K & Ramsden, C 2011, Emergency and Trauma Care for Nurses and Paramedics, Elsevier Australia, Chatswood, NSW, Australia.
Author Natalie Burke

Natalie is a Critical Care Registered Nurse who started off her nursing career in a rural setting before migrating back to Melbourne where she now works in a busy Emergency Department. Natalie comes from a science background, holding a Bachelor of Science (BSc) with majors in anatomy and physiology, before deciding to change career paths into nursing. She undertook a Master of Nursing Practice (MNP) and has never looked back, going on to complete her Graduate Certificate in Emergency Nursing and developing a keen interest for trauma assessment and management. See Educator Profile

Understanding Organ and Tissue Donation - The GIVE Trigger
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