What is generalised pustular psoriasis?
And why you need to learn more about this rare but potentially life-threatening form of psoriasis
Generalised pustular psoriasis (GPP) is the abrupt appearance of sterile pustules covering most of the body, causing painful, burning sensations, fever and chills, usually occurring in adulthood and peaking between 40 and 59 years of age. Although rare, it can be severe and potentially life-threatening. Diagnosing GPP can be difficult not only because of its rarity, but also because of its different presentations and lack of consistent classification among neutrophilic dermatoses – a clinically heterogenous group of rare conditions characterised by the sterile accumulation of neutrophils in the skin.
Misdiagnosis of GPP is common and, as a result, could lead to late referral and treatment initiation. Emergency department (ED) physicians are likely to encounter patients with pustular subtypes and with limited understanding of the presentation and pathogenesis of GPP, could often mistake the flares of sterile pustules for infection. Dermatologists who could diagnose GPP may have limited knowledge of treatments and may need to refer to a colleague with more experience in GPP management.
Learn more about GPP and other neutrophilic dermatoses by enrolling in the free two-part course COMPASS: Coordinating care and iMproving outcomes in Patients with puStular pSoriasis.
After completing the course, you should be able to:
Neutrophilic dermatoses: an overview
Generalised pustular psoriasis
