GPs must be on the lookout for hereditary high cholesterol General practice plays a crucial role in preventing and managing atherosclerotic cardiovascular disease risk, but GPs need to focus on the basics. Recent Australian publications on lipid management, including the 2019 ESC and EAS guidelines and the 2021 consensus statement on familial hypercholesterolaemia, offer valuable guidance. Research stresses the importance of achieving lower LDL-C values for reducing cardiovascular risk, and lipid levels should be managed based on a person's ASCVD risk estimate for optimal outcomes. GPs and primary care teams play a key role in long-term holistic care, but the challenge lies in devising effective management plans and setting achievable CVD risk reduction goals in the face of limited resources in Australian primary care.